Youtube user arglefumph has created a 21-video Nancy Drew Trail of the Twister walkthrough.
Part 1: Off to Oklahoma!
Part 2: Scott, Debbie and the County Siren Puzzle
Part 3: Chase the Mechanic
Part 4: Ma and Pa’s General Store
Part 5: Inside the Mystery Box
Part 6: Frosty Harlow
Part 7: Day Two, Corn Fields and Clouds
Part 8: Circuit Boards
Part 9: Pa’s Puzzles
Part 10: Brooke Tavannah
Part 11: Saving the Prairie Dogs
Part 12: Fixing Frosty’s Camera
Part 13: Fixing the Antennas
Part 14: The Gear Puzzle and Frosty the Drama Queen
Part 15: Nancy the Pied Piper
Part 16: Fixing Scott’s Phone
Part 17: Confronting Chase, Fixing the TV
Part 18: Confronting Frosty, Doppler Puzzle
Part 19: Colored Cables
Part 20: Where’s Scott?
Part 21: The End